Orioles vs. Red Sox Predictions: Home Opener Pick

by | Last updated Mar 31, 2025 | mlb

Boston Red Sox vs. Baltimore Orioles
Date: Monday, March 31st, 2:35 ET
Location: Oriole Park at Camden Yards
TV: MASN
Money Line: Red Sox +123/Orioles -145
Total Line: 9.5

Betting Preview

Here’s our betting preview for the upcoming MLB clash between the Baltimore Orioles and the Red Sox on Monday, March 31st at Oriole Park at Camden Yards. We provide you with a comprehensive analysis, odds, and predictions to help with your handicapping decision or tail our expert based on the projected lineups and listed starting pitchers.

Betting Odds

ML RL Total
BOS +123 +1.5 O 9.5 (-108)
BAL -145 -1.5 U 9.5 (-113)

At 2:35 PM ET, the Red Sox and Orioles face off in an AL East matchup. This one is being played at Oriole Park at Camden Yards in Baltimore, and the Orioles are favored on the money line, with their odds sitting at -145 compared to the Red Sox at +123.

The over/under line is currently at 9.5 runs, and the game can be seen on MASN. Monday’s starting pitching matchup is Sean Newcomb for the Red Sox and Cade Povich for the Orioles.

Red Sox vs. Orioles Projected Lineup

Player Batting Order Position
Jarren Duran 1 LF
Rafael Devers 2 DH
Alex Bregman 3 3B
Trevor Story 4 SS
Rob Refsnyder 5 RF
Triston Casas 6 1B
Kristian Campbell 7 2B
Connor Wong 8 C
Ceddanne Rafaela 9 CF
Sean Newcomb SP


Player Batting Order Position
Ramón Laureano 1 RF
Adley Rutschman 2 DH
Ryan Mountcastle 3 1B
Tyler O’Neill 4 LF
Jordan Westburg 5 2B
Gary Sánchez 6 C
Cedric Mullins 7 CF
Ramón Urías 8 3B
Jackson Holliday 9 SS
Cade Povich SP

Straight Up/Over-Under/ Runline Record

Boston Red Sox: 1-3 SU / OU 0-4 / Runline 1-3
Baltimore Orioles: 2-2 SU / OU 3-1 / Runline 2-2

Red Sox Records & Recent Play

The Red Sox will be looking to get back on track after closing out their series vs. the Rangers with a 3-2 loss. This was especially tough, as they held a lead going into the 6th inning before the Rangers scored two runs in the bottom of the 6th. Boston was the +136 underdog on the road going into this matchup.

Richard Fitts put together a good start for the Red Sox, going six innings and giving up just three runs on six hits. He only had four strikeouts in the outing and took the loss. The Red Sox’s offense scored their only two runs in the 2nd inning and didn’t have another hit until the 6th.

Orioles Records & Recent Play

Baltimore closed out their series vs. the Blue Jays with a 3-1 loss. The Orioles were the +114 underdog on the road. Things started off well for the Orioles, as they got on the board with a run in the 1st inning but gave up the lead right away as the Blue Jays scored twice in the bottom of the first.

Tomoyuki Sugano got the start for the Orioles and took the loss. He only lasted four innings, giving up two earned runs on four hits. The Orioles also wasted a big game from Ryan O’Hearn, who went 2/2 with a double and a run scored.

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Pitching Matchup

Left-hander Sean Newcomb will make his first start of the season for the Red Sox against the Orioles. Last year, Newcomb made seven appearances and went 1-0 with an ERA of 6.3. His WHIP for the season was 1.70, and opponents hit .243 off him. Newcomb’s FIP for the season was 7.07, and he allowed two home runs. His strikeout-to-walk ratio for the season was 0.9, and he averaged 1.1 walks per game.

Left-hander Cade Povich is coming off a season in which he made 16 starts and finished with a record of 3-9. His ERA for the season was 5.20, and he made three quality starts. Povich’s WHIP for the season was 1.43, and he allowed a batting average of .257. Last season, Povich faced the Red Sox twice and went 0-2 with an ERA of 5.28. For the season, he averaged 7.79 strikeouts per nine innings and 3.84 walks per nine innings.

Red Sox vs. Orioles Offense Outlook

Red Sox outfielder Jarren Duran has the highest hits projection of any player in today’s MLB slate. Duran has been swinging a hot bat lately, so he could be a good bet to pick up a few hits in today’s game.

One player to keep an eye on for today’s MLB slate is Tyler O’Neill of the Orioles. He has the highest hits projection of any player in action today, so he could be in line for a productive day at the plate.

Free Red Sox vs. Orioles MLB Pick

This AL East matchup features a pitching matchup of Sean Newcomb for the Red Sox and Cade Povich for the Orioles. Povich will have some pressure on him, getting the start in the team’s home opener, and I think he takes the mound and puts on a good performance vs a Red Sox lineup that hasn’t scored more than three runs since opening the season with five runs. I like Baltimore on the money line.

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