Cleveland Guardians vs. Los Angeles Angels: MLB Betting Preview and Prediction

by | Last updated Apr 6, 2025 | mlb

Cleveland Guardians vs. Los Angeles Angels
Date: Sunday, April 6th, 4:07 ET
Location: Angel Stadium of Anaheim
TV: MLBTV
Money Line: Guardians -123/Angels +106
Total Line: 9

Betting Preview

Here’s our betting preview for the upcoming MLB clash between the Los Angeles Angels and the Guardians on Sunday, April 6th at Angel Stadium of Anaheim. We provide you with a comprehensive analysis, odds, and predictions to help with your handicapping decision or tail our expert based on the projected lineups and listed starting pitchers.

Betting Odds

ML RL Total
CLE -123 -1.5 O 9 (-103)
LAA +106 +1.5 U 9 (-116)

From Angel Stadium of Anaheim in Anaheim, we have an AL matchup between the Guardians and Angels. The Guardians are 3-5 compared to the Angels, who are 5-3. Cleveland comes into the game as the slight moneyline favorite, with their odds sitting at -123, while the Angels are at +106.

First pitch for Sunday’s matchup is set for 4:07 PM ET, and the forecasted temperature is 58 degrees with a clear sky. Tyler Anderson is starting for the Angels, and he is facing off against Luis L. Ortiz for the Guardians. The over/under line is currently at nine runs.

Guardians vs. Angels Projected Lineup

Player Batting Order Position
Steven Kwan 1 LF
José Ramírez 2 3B
Lane Thomas 3 CF
Carlos Santana 4 1B
Kyle Manzardo 5 DH
Jhonkensy Noel 6 RF
Bo Naylor 7 C
Gabriel Arias 8 2B
Brayan Rocchio 9 SS
Luis L. Ortiz SP


Player Batting Order Position
Taylor Ward 1 LF
Nolan Schanuel 2 1B
Mike Trout 3 RF
Jorge Soler 4 DH
Yoán Moncada 5 3B
Logan O’Hoppe 6 C
Luis Rengifo 7 2B
Jo Adell 8 CF
Kevin Newman 9 SS
Tyler Anderson SP

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Straight Up/Over-Under/ Runline Record

Cleveland Guardians: 3-5 SU / OU 5-3 / Runline 3-5
Los Angeles Angels: 5-3 SU / OU 6-2 / Runline 5-3

Thanks to a seven-run 5th inning for the Angels’ offense, they cruised to a 10-4 win over the Guardians in the most recent game of this series. Heading into the game, the Angels were at +127 on the money line.

The starting pitching matchup for this game featured Jack Kochanowicz for the Angels, and he went just five innings while giving up two hits and two earned runs. Tanner Bibee got the start for the Guardians, going four innings and giving up seven runs on eight hits.

Los Angeles got a huge performance from Logan O’Hoppe, as he went 3/5 with a home run and two RBIs. O’Hoppe was one of four Angels hitters to have a multi-hit game.

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Pitching Matchup

Luis L. Ortiz is getting the start for the Guardians on the road against the Angels. In his first start of the season, he took a loss vs. the Padres, going 4 2/3 innings and giving up seven runs on nine hits. He did strike out seven batters but also gave up two home runs.

Tyler Anderson is getting the start for the Angels today as they host the Cleveland Guardians. Anderson is making his second start of the season, and in his first outing, he went five innings and gave up three earned runs on six hits and two homers.

Guardians vs. Angels Offense Outlook

Jose Ramirez has the highest projected hit total on today’s MLB slate. He is a key player to watch for the Guardians as they take on their opponent.

Mike Trout of the Los Angeles Angels is projected to have the most hits in today’s game. Trout is one of the best hitters in baseball and is always a threat to get on base multiple times in a game. Keep an eye on Trout to lead the Angels’ offense in hits today.

Free Guardians vs. Angels MLB Pick

I think with this pitching matchup, there is a potential for a lot of runs, and I’m looking at the over/under line sitting at nine runs, as a good value to take the over. Look for several long balls in this one and a lot of runs.

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