Cardinals vs. Red Sox Prediction: Expert MLB Pick & Buehler vs. Fedde Analysis (4/4)

by | Last updated Apr 4, 2025 | mlb

St. Louis Cardinals vs. Boston Red Sox
Date: Friday, April 4th, 2:10 ET
Location: Fenway Park
TV: NESN
Money Line: Cardinals +121/Red Sox -142
Total Line: 9

Betting Preview

Here’s our betting preview for the upcoming MLB clash between the Boston Red Sox and the Cardinals on Friday, April 4th at Fenway Park. We provide you with a comprehensive analysis, odds, and predictions to help with your handicapping decision or tail our expert based on the projected lineups and listed starting pitchers.

Betting Odds

ML RL Total
STL +121 +1.5 O 9 (-110)
BOS -142 -1.5 U 9 (-110)

From Fenway Park in Boston, we have the Cardinals and Red Sox facing off in an interleague matchup. First pitch for this one is set for 2:10 PM ET, and the forecast calls for cloudy skies and temperatures in the mid to upper 50s.

St. Louis is 4-2 heading into Friday’s game, while the Red Sox have an overall record of 3-4. Boston is currently favored on the money line, with the odds sitting at -142 compared to the Cardinals at +121. Today’s over/under line is at nine runs, and Walker Buehler is the Red Sox starter, while the Cardinals are going with Erick Fedde.

Cardinals vs. Red Sox Projected Lineup

Player Batting Order Position
Lars Nootbaar 1 LF
Willson Contreras 2 1B
Brendan Donovan 3 2B
Nolan Arenado 4 3B
Alec Burleson 5 DH
Iván Herrera 6 C
Jordan Walker 7 RF
Victor Scott II 8 CF
Masyn Winn 9 SS
Erick Fedde SP
Player Batting Order Position
Jarren Duran 1 LF
Rafael Devers 2 DH
Alex Bregman 3 3B
Triston Casas 4 1B
Trevor Story 5 SS
Kristian Campbell 6 2B
Wilyer Abreu 7 RF
Connor Wong 8 C
Ceddanne Rafaela 9 CF
Walker Buehler SP

Straight Up/Over-Under/ Runline Record

St. Louis Cardinals: 4-2 SU / OU 5-1 / Runline 4-2
Boston Red Sox: 3-4 SU / OU 2-5 / Runline 3-4

Cardinals Records & Recent Play

The Cardinals’s offense was hot right out of the gates in their most recent game vs. the Angels, closing out their series with a 12-5 win. After allowing one run to the Angels in the top of the first, the Cardinals responded with three runs of their own. St. Louis went on to add another nine runs in the 4th inning.

Sonny Gray put together a good start for the Cardinals, going six innings and giving up just five hits and one earned run. He also issued only one walk and struck out nine Angels batters. St. Louis’s offense was carried by Iván Herrera, who went 3/4 with three homers and six RBIs.

Red Sox Records & Recent Play

The Red Sox’s offense was hot right out of the gates in their most recent game vs. the Orioles, closing out their series with an 8-4 win. After allowing one run to the Orioles in the bottom of the first, the Red Sox responded with two runs of their own. Boston went on to add another two runs in the 2nd inning.

Tanner Houck got the start for the Red Sox, going four innings and giving up three earned runs on five hits. He only had six strikeouts in the outing but took the loss. Alex Bregman was hot at the plate, going 3/5 with a homer and three RBIs.

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Pitching Matchup

Erick Fedde and the Cardinals are on the road to take on the Red Sox. Fedde got the win in his first start of the season, going six innings and giving up just one earned run. He finished with two strikeouts and allowed two hits.

Walker Buehler will be making his first start of the season at home against the St. Louis Cardinals. Buehler’s first start of the season was on the road against the Rangers, where he took the loss and gave up four runs in 4 1/3 innings of work.

Cardinals vs. Red Sox Offense Outlook

Lars Nootbaar is projected to have the most hits of any player in today’s MLB slate. The Cardinals outfielder has been swinging a hot bat lately, so keep an eye on him to have a productive day at the plate.

One player to keep an eye on in today’s MLB action is Jarren Duran of the Boston Red Sox. Duran has the highest hits projection of any player in action today, so he could be in line for a big day at the plate. If you’re looking to target a player who could have a big offensive performance, Duran is a strong option to consider.

Free Cardinals vs. Red Sox MLB Pick

For Friday’s afternoon matchup in Boston, I think Walker Buehler locks things down for the Red Sox and gets them back to .500 for the season. The Cardinals are coming off a 12-run outburst vs the Angels, but Buehler should keep them in check today. I like the Red Sox on the money line.

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