2025 MLB Most Wins: Top Betting Picks and Dark Horse Predictions

After analyzing the rosters, rotations, and team forecasts for the 2025 MLB season, I’ve identified my top three favorites to lead the league in wins, plus an intriguing dark horse that could surprise everyone.

Top 3 Favorites for Most Wins in 2025

1. Los Angeles Dodgers (-220)

The defending World Series champions remain the clear frontrunner with their loaded roster. The Dodgers have the most complete team in baseball, featuring a rotation of Blake Snell, Yoshinobu Yamamoto, Tyler Glasnow, and Roki Sasaki that is unmatched in depth and talent. Their lineup with Ohtani, Betts, and Freeman at the top is simply devastating. Manager Dave Roberts has all the pieces to make a run at 100+ wins, especially if Ohtani returns to his two-way form later in the season.

2. Atlanta Braves (+900)

Despite Ronald Acuña Jr.’s injury to start the season, the Braves possess enough firepower to lead MLB in wins. Atlanta’s rotation anchored by Cy Young winner Chris Sale should be formidable, with Reynaldo López and Spencer Schwellenbach providing excellent depth. The lineup still features Matt Olson, Austin Riley, and Marcell Ozuna, who had a career year in 2024. Once Acuña and Spencer Strider return, this team has tremendous upside. Their organizational excellence and track record of regular season success make them an excellent value at +900.

3. Chicago Cubs (+2800)

At these odds, the Cubs offer tremendous value. Chicago made one of the offseason’s biggest moves by adding Kyle Tucker to a lineup that already includes Ian Happ, Seiya Suzuki, and Dansby Swanson. Their rotation featuring Shota Imanaga, Jameson Taillon, and Justin Steele is solid with good depth. New manager Craig Counsell has a history of maximizing roster talent, and the NL Central appears more winnable than other divisions. At +2800, they’re my favorite value play among the top contenders.

Dark Horse: Tampa Bay Rays (+10000)

Despite playing in a temporary home stadium following hurricane damage, the Rays at 100-to-1 odds represent incredible value. Tampa Bay’s rotation could be the best in baseball if Shane McClanahan, Drew Rasmussen, and Shane Baz stay healthy after returning from injuries. The lineup features rising star Junior Caminero, and the organization consistently gets the most out of its roster. Their organizational excellence routinely outperforms expectations, and the temporary move to the more hitter-friendly Steinbrenner Field could actually boost their offense. At +10000, the Rays are the ultimate high-upside longshot.

Conclusion

While the Dodgers remain the obvious favorite, both Atlanta at +900 and Chicago at +2800 offer better value for bettors. The Rays at +10000 represent the ultimate high-risk, high-reward option for those looking for a longshot with legitimate upside.

For the latest MLB odds and to place your bets, visit BetOnline.