Indiana at Michigan State Point Spread Pick | Week 10

No. 13 Indiana Hoosiers at Michigan State Spartans Betting Preview

Where: Spartan Stadium, East Lansing, MI

When: Saturday, November 2, at 3:30 PM EST

Watch: Peacock

Betting Odds

Spread: Ind -7.5/MSU +7.5

Over/Under: 51.5

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The Indiana Hoosiers are riding a wave of momentum this season as they visit the Michigan State Spartans in a Big Ten showdown. Indiana enters the game with an impressive 8-0 record, marking one of the best starts in program history. This matchup is another test as the Hoosiers seek to keep their flawless season alive, but the Spartans are determined to defend their home turf, boasting a 3-1 record at Spartan Stadium this year. With both teams vying for different stakes—Indiana eyeing a playoff berth and Michigan State battling for bowl eligibility—this game is set to draw national attention. Here’s our betting breakdown for Saturday afternoon.

Indiana Hoosiers Betting Analysis

Indiana’s offense has been electric this season, averaging 46.5 points per game, ranking them second nationally. Led by QB Kurtis Rourke, who averages 287 passing yards per game, the Hoosiers’ offense converts over 50% of third-down opportunities and ranks 10th in total yards per game. Justice Ellison anchors the run game with 637 rushing yards, averaging an impressive 6.2 yards per carry.

Defensively, Indiana complements its offense with an equally effective unit. The Hoosiers rank 18th in total defense, allowing just 14.1 points per game and excelling against the run, where they sit 7th nationally. Indiana’s balanced approach has proven difficult for opponents to match, making them a well-rounded team ready to challenge the Spartans.

Michigan State Spartans Betting Analysis

Michigan State sits at 4-4 and is aiming for bowl eligibility with a much more conservative game plan. Led by quarterback Aidan Chiles, the offense has struggled with turnovers, as Chiles has thrown nine interceptions against seven touchdowns. The Spartans average 21 points per game but will be challenged to keep up with Indiana’s high-powered offense.

Michigan State’s defense has been the highlight of their season, allowing only 21.3 points per game. Their front seven has been effective in limiting opponents, holding teams to 186.2 passing yards per game and recording 15 sacks so far. This defensive strength is crucial if Michigan State hopes to keep the game within reach against a potent Indiana offense.

My Pick: Indiana Hoosiers -7.5 (-110)

Indiana’s dominance on both sides of the ball makes them a strong pick to cover the 7.5-point spread. Despite a thumb injury for Rourke, he is expected to play, and Indiana’s deep running back corps can sustain the offense if needed. Michigan State has struggled against powerhouse teams this season, evidenced by their blowout losses to Oregon and Ohio State. While Michigan State’s home field advantage is notable, it won’t be enough to contain Indiana’s balanced attack. Back the Hoosiers to cover the spread and secure another double-digit win.

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